Progressive supranuclear palsy (PSP), also known as the Steele-Richardson- Olszewski syndrome, is a tauopathy and considered a neurodegenerative disease. La parálisis supranuclear progresiva o síndrome Steele-Richardson-Olszewsky, es una enfermedad rara, degenerativa, producida por el deterioro y muerte. PDF | Summary Introduction: Progressive supranuclear palsy (PSP) is the second most common parkinsonism. Vertical gaze palsy and postural instability with.

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Views Read Edit View history. Physical medicine and rehabilitation. The initial symptoms in two-thirds of cases are loss of balance, lunging forward when mobilizing, fast walking, bumping into objects or people, and falls.

Progressive supranuclear palsy

Approximately six people perpopulation have PSP. Fifty years of progressive supranuclear palsy. Extrapyramidal and movement disorders Cognitive disorders Rare diseases Syndromes. Progressive supranuclear supranuclearr PSP ; or the Steele—Richardson—Olszewski syndromeafter the doctors who described it in is a degenerative disease involving the gradual deterioration and death of specific volumes of the brain.

The visual symptoms are of particular importance in the diagnosis of this disorder.

Other genes, as well as environmental toxinsare being investigated as other possible contributors to the cause of PSP. PSP is essentially a clinical diagnosis, however, given the bleak prognosis, Magnetic Resonance Imaging MRI of the brain is performed in all patients to exclude alternative diagnoses and to look for supporting features of PSP. Clumps of tau are also characteristic of other neurodegenerative disorders, such as Alzheimer’s disease.


Dugger PhD, Joseph G. There’s no cure supranuvlear progressive supranuclear palsy, so treatment focuses suprauclear managing the signs and symptoms. Kim JH, et al.

Progressive supranuclear palsy – Wikipedia

MR imaging index for differentiation of progressive supranuclear palsy from Parkinson disease and the Parkinson variant of multiple system atrophy. MRI may show atrophy in the midbrain with preservation of the pons giving a “hummingbird” pqralisis appearance and Mickey Mouse sign [21].

To avoid injuries due to falling, a walker or a wheelchair may be used. A variant in the gene for tau protein called the H1 haplotypelocated on chromosome 17has been linked to PSP. Supranuckear reports of rehabilitation programs for patients with PSP generally include limb-coordination activities, tilt-board balancing, gait trainingstrength training with progressive resistive exercises and isokinetic exercises and stretching of the neck muscles.

Differentiating progressive supranuclear palsy from Parkinson’s disease by MRI-based dynamic cerebrospinal fluid flow. Current Treatment Parallisis in Neurology. How to cite this article. Rarely, progressive supranuclear palsy occurs within a family.

Journal of Neuropathology and Experimental Neurology. The only proven risk factor for progressive supranuclear palsy is age. Other common early symptoms are changes in personality, general slowing progreziva movement, and visual symptoms. Journal of Neurology, Neurosurgery and Psychiatry. We present the case of an adult patient who had dementia and parkinsonism refractory to levodopa with supranucldar falls in whom typical findings of PSP were documented in MRI.


Make an appointment with your doctor if you experience signs and symptoms of progressive supranuclear palsy. A poor response to levodopa along with symmetrical onset can help differentiate this disease from PD. National Institute of Neurological Disorders and Stroke. Uses authors parameter CS1 maint: Poliomyelitis Demyelinating disease Transverse myelitis Tropical spastic paraparesis Epidural abscess.

The cause of PSP is unknown. These tangles are often different from those seen in Alzheimer’s disease, but may be structurally similar when they occur prpgresiva the cerebral cortex. From Wikipedia, the free encyclopedia. Notably, the ophthalmoparesis experienced by these patients mainly concerns voluntary eye movement and the inability to make vertical saccadeswhich is often worse with downward saccades.