COPROCESSED EXCIPIENTS PDF
Co-processed excipients have been developed to handle changes in the physical properties of particles at sub-particle levels. By co-processing two excipients. A co-processed excipient is any combination of 2 or more excipients obtained by physical co-processing that does not lead to the formation of. co-processed excipients ppt. 1. 1; 2. CO-PROCESSED Presented by- Under the guidance ofMr. Bhaskar N. Bangar Dr. N. H. Aloorkar.
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Hence, this study involves both advantages of wet granulation and direct compression as atorvastatin calcium is very slightly soluble in water. Inhibition of the enzyme decreases de novo cholesterol synthesis, increasing low-density lipoprotein LDL receptors on hepatocytes.
For this purpose, a beaker was filled with 10 ml of water. All the pre-compression parameters were calculated for the co-processed excipient granules, granules of pure acacia and CaCO 3 in addition to the friability of granules. However, the direct compression process is highly influenced by functionality of parent excipients. The properties are evaluated by Hausner’s ratio and Carr’s index values. Hence, these excipients should have good flow properties and compatibility with each other which can be achieved by combining the properties of excipients through co-processing technique.
The excipients acacia and CaCO 3 were used in the present study. Atorvastatin calcium shows pH dependent solubility and is soluble in alkaline medium.
Sufficient quantity of water was added in colrocessed cylinder and shaken vigoursly. The tablet containing coprocessed mucilage as a superdisintegrant shows fast disintegration and drug release than coprocessed SSG. Like other statins, atorvastatin also reduces blood levels of triglycerides and slightly increases levels of high-density lipoprotein HDL -cholesterol. The direct compression technique involves the compression of a dry blend of powders that comprises drugs and various excipients.
Results of the evaluation study have been depicted in Table 1. The stability studies were carried out for the optimized formulation. The coprocessed SSG shows disintegration time upto 11 sec. Due to its high swelling index the coprocessed mucilage shows faster disintegration than the coprocessed SSG. Placebo tablets were prepared containing coprocessed mucilage as superdisintegrant in different concentration and evaluated for disintegration time. The results reveal that mucilage exhibited the fair flow properties.
Preparation of coprocessed superdisintegrant A blend of Mannitol- Mucilage was added to 65 ml of isopropyl alcohol in different concentrations. A beaker was filled with dissolution medium and suspended in water bath.
Formulation and Evaluation of Coprocessed Excipient for Mouth Dissolving Formulation
The friability of the granules was found out using Roche friabilator. The angle of repose was then calculated using following formula.
These coprocessed excipients interact at sub particle level. Marcel Dekker Inc; Micromeritic properties of co-processing excipients formulated with different ratios of acacia mucilage and calcium carbonate.
The seeds were soaked in distilled water for 12 hrs and boiled for 30 min. Also if a physical mixture of super disintegrant is used in high speed tableting, the problem of excipienhs of the super disintegrants may be encountered. For the friability, twenty undusted tablets were weighted, put in the friabilator Electrolab, EF-1W for cycles and re-weighted.
The co-processed excipients were formed using granulation technique. The coprocessed excipient improves its flowability of parent excipients.
Keywords Mouth dissolving tablet; Terbutaline sulphate; Coprocessed excipient; Ocimum bascilium ; Superdisintegrant Introduction Oral solid dosage forms are most commonly preferred dosage form due to its ease of manufacturing, user friendly nature and capital interest also.
In water, sodium starch glycolate swells to up to times its volume whereas mucilage swells upto The bulk volume was noted.
In addition, Mannitol is non-hygroscopic and may thus be used with moisture-sensitive ingredients. The protocol of stability studies was in compliance with ICH guidelines for stability testing intended for the zone IVa.
Mouth dissolving tablet; Terbutaline sulphate; Coprocessed excipient; Ocimum bascilium ; Superdisintegrant. The European Pharmacopoeia describes ODTs as uncoated tablets intended to be placed in the mouth where they disperse rapidly before being swallowed as suspension and coprlcessed tablets should disintegrate within 3 min [ 3 ].
The tablet was put in the beaker and whole assembly was gently stirred, the time for the tablet to completely disintegrate into fine particles was noted [ 16 ]. The simplicity and low capital investment of the direct-compression process have positioned it as a preferred alternative. Crystal engineering and particle design for the powder compaction process. Saha S, Shahiwala AF Multifunctional coprocessed excipients for improved tabletting performance. Various ratios of the co-processing excipients were formulated by granulation technique coproceesed the blend properties were evaluated by their Hausner’s ratio and Carr’s index values.
Studies on direct compression of tablets. The flow properties may be improved by the method of coprocessing which minimizes number of excipients and improves its functionality.
Ten randomly selected tablets were weighed and placed in the friabilator. Conclusion Mouth dissolving tablet of Terbutaline sulphate containing Ocimum bascilium as a superdisintegrant was prepared successfully.
A total of 3 g of granules were weighed and transferred to a measuring cylinder. This article has been cited by other articles in PMC.